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Recent studies suggest that combining NAMPT inhibitors with other therapies could enhance their efficacy and reduce resistance in cancer treatment, as shown in various preclinical animal models 217,218

We would like slightly faster confirmation during peak periods, but overall reliable

However, controlled human trials evaluating these effects are lacking

There is a theoretical --- though as yet unproven in humans --- risk that long-term or high-dose use could stimulate growth in existing malignant or pre-malignant cells

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For example, some gut microbes produce short-chain fatty acids that have been shown to stimulate GLP-1 secretion in the gut