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Studies show that sustained weight reduction improves endothelial function, reduces inflammatory markers, and decreases venous stasisall factors that contribute to clot formation

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This indicates that methionine deprivation imposes further stress on mitochondrial function, thereby creating a synergistic cancer-suppressing effect with the functions of these genes

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Despite that these studies indicate a plausibly important role of iron homeostasis in BD pathogenesis, the literature is extremely poor in clinical studies on brain iron accumulation in BD either in postmortem tissues or assessed by MRI-based quantitative susceptibility mapping (QSM)

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