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Can J Microbiol 67:687702

As women move through perimenopause and menopause, declining estrogen levels change how the body stores fat, responds to insulin, and regulates energy

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The difference is driven by Mounjaro's dual GIP and GLP-1 receptor activation versus semaglutide's single GLP-1 receptor activation

To test whether the truncated peptides are only functional in the context of the fusion receptors, we used synthetic peptides of GLP-1 and EX4 that lack the first two residues, GLP-1(9-39) and EX4(339)

However, because MOTS-c affects glucose metabolism, patients on diabetes medications require careful monitoring and potential dose adjustments during the protocol