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Studies examining the timing of combined administration have consistently shown that simultaneous or near-simultaneous administration produces maximal synergy, with the synergistic component declining as the interval between administrations increases beyond 15-30 minutes

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A level of adherence at or above 80% has been considered sufficient for effective type 2 diabetes treatment, since that level has been associated with a reduction in hospitalizations and mortality [10]

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EBioMedicine 83 , 104210 (2022)