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The Thiazolidinediones Or Sulfonylureas and Cardiovascular Accidents Intervention Trial (TOSCA.IT) is the only major trial to have assessed the CVOT from using older diabetes drugs as second-line agents to metformin in T2D individuals with mild-to-moderate cardiovascular risk [50]

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The baseline characteristics of the included female participants are presented in Table 1, and the differences in dietary vitamin B2 intake, femur BMD in different regions, and hip fracture frequency between OP and non-OP groups were reported in Table

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