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Consistent with the incretin-mediated delivery of the PPAR// agonist, the metabolic effects of GLP-1GIPLani were blunted in DIO mice with pharmacological or genetic inhibition of GLP-1R, GIPR or PPAR, and vanished in double-incretin receptor knockout (DIR-KO) mice

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Start: 200 mcg once daily Increase: Add ~200 mcg every 2 weeks as tolerated Target Range: 400600 mcg once daily Frequency: Once daily Cycle Length: Typically 812 weeks Timing: Any consistent daily time

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Genomics 72 , 4350 (2001)

The head-to-head SURMOUNT-5 trial directly comparing Tirzepatide and Semaglutide showed Tirzepatide producing 15.7kg weight loss versus Semaglutides 9.7kg

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