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These include: Nausea (affecting 2040% of patients initially) Vomiting and diarrhoea Constipation Abdominal discomfort or bloating Reduced appetite These symptoms are usually mild to moderate and tend to diminish over several weeks as the body adjusts to the medication

Bupropion-naltrexone (Contrave) Contrave combines an antidepressant (bupropion) with an opioid antagonist (naltrexone) to target reward-based eating behaviors

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came to a similar conclusion: intranasal application was more effective than buccal administration because drugs might be swallowed by uncooperative children before there is sufficient time for absorption (33)