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Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration

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Spagnuolo C, Russo GL, Orhan IE, Habtemariam S, Daglia M, Sureda A, Nabavi SF, Devi KP, Loizzo MR, Tundis R, Nabavi SM (2015) Genistein and cancer: current status, challenges, and future directions

Existing evidence comes mainly from observational clinical studies

Excellent dietary sources include: Meat : beef, lamb, and pork (particularly liver, though liver should be limited in pregnancy due to high vitamin A content) [3] [4] Fish : salmon, sardines, and tuna (limit tuna to 2 steaks or 4 medium cans weekly due to mercury content) Poultry : chicken and turkey Dairy products : milk, cheese, and yoghurt Eggs : particularly the yolk For women following plant-based diets , obtaining sufficient B12 from food alone is challenging, as plant foods do not naturally contain bioavailable B12

Therefore, patients taking allopurinol and febuxostat treat GA through synergism: reducing FA levels to suppress inflammatory responses and inhibiting xanthine oxidase to lower uric acid levels