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This can happen gradually, so you may not notice the signs right away

Cardiovascular effects: Glucagon receptor agonism (via retatrutide) and GLP-1 receptor agonism have been associated with modest increases in heart rate as a class effect

When traveling, the medication should be transported in an insulated container with ice packs if refrigeration will not be available, taking care to prevent direct contact between the medication and ice to avoid freezing