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GSH also modulates cell proliferation, apoptosis, immune function, and fibrogenesis (Lu, 2013)

In addition, extracellular lactate stabilizes HIF-2, and HIF-2 then transactivates MYC, increasing the levels of glutamine transporters and GLS1, in turn resulting in increased glutamine catabolism 72

identified in TP53 mutant cell lines, in vivo models, and primary patient samples that the combination of APR-246 and azacitidine results in a synergistic pro-apoptotic effect as well as a dramatic reduction in cell proliferation via cell cycle arrest (Figure 1)