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To establish whether differences in binding affinity could contribute to the elevated GLP-1 levels in PAM T2D-risk allele carriers we measured receptor binding affinity in competition with 125 I-GLP-1(736 amide) for both the amidated and non-amidated forms of GLP-1 demonstrating that they are equipotent (Additional file 2: Fig

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J Physiol Sci (2018) 68(1):1931