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2020;52(11): e13889

Brekhman y Torres fueron los creadores de los inmunoterpicos adaptgenos cubanos, en 1977

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Consistent use of high-quality supplements is key, and many individuals report a noticeable difference after 4 to 8 weeks of regular use

In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/P)-induced Parkinsons disease model mice, MPTP/P injection increased the ratio of Bax/Bcl-2 and the expression of caspase-3 in the hippocampus, while berberine administration reversed these effects ( In addition, animal experiments and cell experiments have confirmed that berberine reduces the levels of extracellular and intracellular A, increases the levels of LC3-II, Beclin-1, hVps34 and cathepsin-D, and reduced the levels of P62, Bcl-2, amyloid precursor protein (APP), and beta-secretase 1 (BACE1)

Visualization was contributed by EC, SM, MD, AD, TC, DL, GC, CL, VM, RG, FCo, KA, and LB