SIRT1 (GlcNAc D548) Rabbit Polyclonal Antibody, 50ul Multi-Layer Cell Culture System The protein may play an

The protein may play an important role in the epigenetic control of chromatin structure and gene expression

The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete

The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines

This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members

and targets specific transcription factors

SIRT1 (GlcNAc D548) Rabbit Polyclonal Antibody, 50ul Multi-Layer Cell Culture System The protein may play anThis gene encodes a member of the sirtuin family of proteins homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular