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A venomous desert lizard that rarely eats accidentally providing the blueprint for one of the most widely used diabetes and obesity treatments in the world is the most unexpected scientific origin story of modern medicine So this is where they got the idea for Ozempic from Research on the venom of the Gila monster revealed a molecule called exendin-4 that mimics the human hormone Glucagon-like peptide-1, which regulates insulin, appetite, and digestion

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Mouse liver In mice, GLP-1 receptor expression was assessed using immunohistochemistry in three liver lobes from each of one chow/vehicle dosed and four DIO-NASH vehicle or CDA-HFD vehicle mice