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doi: 10.3389/fphar.2025.1591825 Received 11 March 2025 Accepted 28 August 2025 Published 08 October 2025 Volume 16 - 2025 Edited by Er Sheng Gong, Gannan Medical University, China Reviewed by Guillermo Federico Spitzmaul, National Scientific and Technical Research Council (CONICET), Argentina Leonardo Dionisio, National Scientific and Technical Research Council (CONICET), Argentina Updates Copyright 2025 Giannini, Soldi, Elli, Sagheddu, Castagnetti, Viciani, Salvini, Battistuzzi, Milazzo, Alibrandi and Sidoti

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High oxidative stress can: Damage ovarian cells Disrupt follicle development Affect egg quality Glutathione supports ovarian health by: Protecting cells from oxidative damage Supporting normal cellular function Supporting normal cellular function This is why glutathione is often discussed in PCOS-related fertility and wellness research as support , not treatment

Cryo-EM data collection Grids were screened for ice thickness and particle density using a ThermoFisher Talos Arctica transmission electron microscope (TEM) at 200 kV

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