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At the end of the experiment (day 52), all rats were euthanized

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Maximal reduction of liver fat appears to require both inhibition of hepatic de novo lipogenesis and suppression of adipose tissue lipolysis ( in vitro potency of pegbelfermin as an agonist of FGFR1c, FGFR2c and FGFR3c has not been reported, the modest induction of adiponectin in humans suggests that it exerts minimal action through adipose tissue FGFR1c in humans

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