VH 298 20046 Skrepnik N

Skrepnik N

Discovery of non-covalent inhibitors of the SARS main proteinase 3CLpro

and inhibits the enzyme with an IC50 of 0

MLN2238 (7 mg/kg) shows greater efficacy at a 0

Indisulam (E7070)

VH 298 20046 Skrepnik NVH 298 is a potent VHL inhibitor that stabilizes HIF and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL: HIF protein protein interaction downstream of HIF hydroxylation by PHD enzymes. VH298 represents a high quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. Product information CAS Number: 2097381 85