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XL019 - CAS# 945755-56-6 nin Reduction in prostaglandin E2 synthesis

XL019 - CAS# 945755-56-6 nin Reduction in prostaglandin E2 synthesis

Name: XL019 - CAS# 945755-56-6 nin Reduction in prostaglandin E2 synthesis
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XL019 - CAS# 945755-56-6 nin Reduction in prostaglandin E2 synthesisXL019 is an orally bioavailable inhibitor of Janus associated kinase 2 (JAK2) with potential antineoplastic activity. XL019 inhibits the activation of JAK2 as well as the mutated form JAK2V617F, which may result in the inhibition of the JAK STAT signaling pathway and may induce apoptosis. The JAK2 mutated form JAK2V617F has a valine to phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival. Product

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Description

Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma

McGreivy J

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803712-67-6 (Obatoclax free base)

J Cardiovasc Pharmacol

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