Rat Granzymes B, GZMS-B ELISA Kit, 96T Enzyme Activity Assays and epithelial carcinogenesis
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Rat Granzymes B, GZMS-B ELISA Kit, 96T Enzyme Activity Assays and epithelial carcinogenesisAbundant protease in the cytosolic granules of cytotoxic T cells and NK cells which activates caspase independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin E (GSDME), releasing the pore forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of
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