K145 Hydrochloride Size:Solid 2 mg BLU-9931 shows dose-dependent inhibition of

BLU-9931 shows dose-dependent inhibition of the signaling cascade downstream of FGFR4

Tolfenamic acid interferes with synthesis of β-amyloid precursor protein

Chemical Name: 3-((1r

is an aromatic guanylhydrazone compounds with antimalarial activity

including T315I

K145 Hydrochloride Size:Solid 2 mg BLU-9931 shows dose-dependent inhibition ofK145 is a selective sphingosine kinase 2 (SphK2) inhibitor and anticancer agent. K145 inhibited the activity of SphK2 in a dose dependent manner with an IC50 of 4. 300. 06 M. K145 also exhibited inhibitory effects on the growth of U937 cells as well as apoptotic effects in U937 cells. K145 exhibits comparable in vivo anti tumor activity to tamibarotene, while concomitantly exhibiting less toxicity in this U937 xenograft cancer model. Product