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However, the discovery of functional extrinsic death receptor-mediated eryptosis and necroptosis of erythrocytes associated with the necrosome formation opens new horizons for our understanding of the possible role of caspases in mature erythrocytes, since caspase-8 might be involved in coordinating the cell fate of mature erythrocytes

Dec 2017;33(12):963-967

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Although these trials primarily enrolled individuals with relatively low DKD risk and were not designed to evaluate kidney outcomes specifically, exploratory analyses consistently indicated slower kidney disease progression across diverse eGFR and albuminuria levels [39-44]

Untreated PANC-1 cells displayed abundant JC-1 aggregates, indicative of healthy mitochondria, whereas treatment with vesicles resulted in predominantly JC-1 monomers, suggesting a loss of mitochondrial potential