ADC Toxin Monomethyl auristatin F (MMAF) - CAS# 745017-94-1 Catalog No.:T60002-10S activates human GPR84 in the

activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay

ACY-1215 was used at 1 µM final concentration in vitro and in cellular assays

It induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres

(2013) ACS Chem Biol

2 mg solid each for the following compounds:

ADC Toxin Monomethyl auristatin F (MMAF) - CAS# 745017-94-1 Catalog No.:T60002-10S activates human GPR84 in theMMAF (Monomethylauristatin F) , CAS No. 745017 94 1, is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN CD19A. Product information CAS Number: 745017 94 1 Molecular Weight: 731. 96 Formula: C39H65N5O8 Chemical Name: (S) 2 ((2R,3R) 3 ((S) 1 ((3R,4S,5S) 4 ((S) N,3 dimethyl 2 ((S) 3