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The authors concluded, "Treatment with GLP-1 receptor agonists was associated with lower all-cause mortality among patients with type 2 diabetes, advanced-stage CKD, and ESKD than was treatment with DPP-4 inhibitors

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Key experimental observations include: Preserved Bone Formation: Rodent models demonstrate maintained periosteal activity and longitudinal growth rates despite controlled dosing, indicating localized skeletal responsiveness without broad endocrine activation