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Oral semaglutide is the first oral GLP 1 RA proven to reduce MACE in high risk T2DM patients, extending cardiovascular protection beyond injectable formulations. SOUL Trial: Oral Semaglutide & Cardiovascular Outcomes in T2DM Abstract 4351008: Comparing Cardiovascular Outcomes in New Users of Oral Semaglutide Versus Other Noninsulin Glucose Lowering Therapies Circulation soul trial oral semaglutide cardiovascular outcomes soul trial results European New in the May 29, 2025, issue of NEJM: Sotatercept in Pulmonary Arterial Hypertension (ZENITH phase 3 trial) https: nej.md 4iYkLbj Oral Semaglutide and Cardiovascular Outcomes (SOUL trial) https: nej.md 4hHII5M Upadacitinib for Giant Cell Arteritis Oral Semaglutide's Impact on Cardiovascular Events in Type 2 Diabetes Patients with Cardiovascular and Kidney Disease: SOUL Trial Results PPTX Frontiers Effects of subcutaneous or oral semaglutide on cardiovascular outcomes in patients with type 2 diabetes mellitus: a meta analysis of randomized controlled trials
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