BAY 61-3606 - CAS# 732983-37-8 Size:Solid 2 mg Gonzales IM

Gonzales IM

51-14)35(46)27(7)54-31/h22-37

Endothelial cells treated with 1 microM 4-HPR fails to form tubes

InChi: InChI=1S/C15H10O5/c16-6-10-11(17)5-9-12(15(10)20)14(19)8-4-2-1-3-7(8)13(9)18/h1-5

D-(+)-Glucose

BAY 61-3606 - CAS# 732983-37-8 Size:Solid 2 mg Gonzales IMBAY 61 3606 is a potent (Ki = 7. 5 nM) and selective inhibitor of Syk kinase. BAY 61 3606 inhibited not only degranulation (IC50 values between 5 and 46 nM) but also lipid mediator and cytokine synthesis in mast cells. BAY 61 3606 was highly efficacious in basophils obtained from healthy human subjects (IC50 = 10 nM) and seems to be at least as potent in basophils obtained from atopic (high serum IgE) subjects (IC50 = 8. 1 nM). B cell receptor