GW 5074 - CAS# 220904-83-6 Catalog No.:M10941-10 Smiles: COCCOC1C=CC(=CC=1)NC1=NC(NC2=CC(=CC=C2)NC(=O)C=C)=C(F)C=N1

Smiles: COCCOC1C=CC(=CC=1)NC1=NC(NC2=CC(=CC=C2)NC(=O)C=C)=C(F)C=N1

and inhibits spontaneous as well as interleukin 2-induced growth of mycosis fungoides (MF) tumor cells with IC50 values of 75 μM and 20 μM

23S)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4

3-dimethyl-7-oxo-4-thia-1-azabicyclo[3

likely at the 5-HT2A

GW 5074 - CAS# 220904-83-6 Catalog No.:M10941-10 Smiles: COCCOC1C=CC(=CC=1)NC1=NC(NC2=CC(=CC=C2)NC(=O)C=C)=C(F)C=N1GW5074 is a c Raf inhibitor. GW5074 has no direct effect on the activities of several apoptosis associated kinases when assayed in vitro. In contrast to its effect in vitro, treatment of neurons with GW5074 causes c Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf MEK ERK pathway. GW5074 prevents neurodegeneration and improves behavioral outcome in an animal model of Huntington's disease. GW5074 could have