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The use of NNMT inhibitors as a potential obesity treatment has been investigated preclinically 8,9,13 , and observational clinical data suggests that increased NNMT expression and activity correlate with increased incidence of Type 2 diabetes (T2D) and risk of obesity, respectively 10,11

Its mechanism is fascinatingly complex

This isolation reinforces perceptions of exclusion, while socio-economic trends, such as the emigration of the youngest and highly educated population, further deprive these regions of innovation and creativity