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There seems to be a genetic predisposition, and specific genes associated with the immune system may contribute to the development of autoimmune diseases

Genet Med 17 (1): 70-87, 2015

In our South Florida and Doral patient population, where chronic UV exposure accelerates the cellular aging timeline faster than in most other US markets, the combination of Nrf2 antioxidant activation and epigenetic repair makes Epithalon a particularly well-matched tool for the local clinical context

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The characteristic image of MC is granular or reticular brownish pigmentation distributed in part or the whole colonic mucosa under endoscope (Grilo et al., 2014)